Antimitochondrial antibody(AMA)-negative but antinuclear antibody(ANA)-positive primary biliary cirrhosis(PBC) developed in HLA-identical sisters.
نویسندگان
چکیده
منابع مشابه
Long-term outcomes in antimitochondrial antibody negative primary biliary cirrhosis.
OBJECTIVES Antimitochondrial antibodies (AMA) are a sensitive and specific marker for primary biliary cirrhosis (PBC). AMAs are present in 95% of patients with PBC. However, 5% do not have AMAs and data on these patients is scarce. We aim to evaluate the long-term outcomes of patients with AMA negative PBC. METHODS A retrospective chart review of 71 AMA negative PBC patients. Disease presenta...
متن کاملComparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis.
UNLABELLED Substantial evidence supports dysregulated B-cell immune responses in patients with primary biliary cirrhosis (PBC), including the presence of serum antimitochondrial antibodies (AMAs). However, recent reports from murine models of PBC suggest that B cells may also provide regulatory function, and indeed the absence of B cells in such models leads to exacerbation of disease. The vast...
متن کاملAntimitochondrial and antinuclear antibodies in primary biliary cirrhosis: an update in relation to their biochemical characterization and clinical significance.
Antimitochondrial antibodies are found in 85 to 95% of patients with primary biliary cirrhosis. Nine different patterns have been identified but only four are associated with primary biliary cirrhosis. Anti-M2 antibodies are specific for the disease. The M2 antigen was found to be composed of five antigen determinants and related to the E2 component of three multienzyme complexes located within...
متن کاملPrimary biliary cirrhosis in twin sisters.
Primary biliary cirrhosis in twin sisters is described. The incidence of this rare disease in young women is high but whether there is any genetic or familial association in twin sisters is not known.
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1. Gandhi MK, Khanna R. Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis. 2004;4:725-738. 2. Hislop AD, Taylor GS, Sauce D, Rickinson AB. Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Annu Rev Immunol. 2007;25: 587-617. 3. Gandhi MK, Wills MR, Okecha G, et al. Late diversification in the clonal composition...
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ژورنال
عنوان ژورنال: Kanzo
سال: 1993
ISSN: 0451-4203,1881-3593
DOI: 10.2957/kanzo.34.995